Integration of enzyme activities into metabolic flux distributions by elementary mode analysis
نویسندگان
چکیده
منابع مشابه
Metabolomics integrated elementary flux mode analysis in large metabolic networks
Elementary flux modes (EFMs) are non-decomposable steady-state pathways in metabolic networks. They characterize phenotypes, quantify robustness or identify engineering targets. An EFM analysis (EFMA) is currently restricted to medium-scale models, as the number of EFMs explodes with the network's size. However, many topologically feasible EFMs are biologically irrelevant. We present thermodyna...
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MOTIVATION Elementary flux mode (EFM) is a fundamental concept as well as a useful tool in metabolic pathway analysis. One important role of EFMs is that every flux distribution can be decomposed into a set of EFMs and a number of methods to study flux distributions originated from it. Yet finding such decompositions requires the complete set of EFMs, which is intractable in genome-scale metabo...
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As genome-scale metabolic networks are being reconstructed with increasing accuracy, new methods are needed to understand the systemic biochemical properties of these large networks. The behaviour of complex systems of interacting components cannot be comprehended by the sole characterization of their individual components or pair-wise relations, because new properties emerge from the interacti...
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Elementary flux modes (EFMs) emerged as a formal concept to describe metabolic pathways and have become an established tool for constraint-based modeling and metabolic network analysis. EFMs are characteristic (support-minimal) vectors of the flux cone that contains all feasible steady-state flux vectors of a given metabolic network. EFMs account for (homogeneous) linear constraints arising fro...
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Preface This dissertation is submitted for the partial fulfillment of the degree of doctor of philosophy. modes for fast and efficient analysis of metabolic networks, Biochem. Eng. Integration of omics into metabolic flux distribution by complementary elementary mode analysis for large-scale metabolic networks, 169 th OMICS Group Conference, 3 mode analysis for large-scale metabolic networks.
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ژورنال
عنوان ژورنال: BMC Systems Biology
سال: 2007
ISSN: 1752-0509
DOI: 10.1186/1752-0509-1-31